Endocrine Abstracts

Background: Cystic Fibrosis related diabetes affects 40-50% of adults with cystic fibrosis (CF). This can significantly affect pulmonary function and life expectancy. Kaftrio (Ivakaftor, tezacaftor and elexacaftor) has recently been licensed for use in CF. Previous data highlight that glucose regulation may be altered on commencing this treatment.Methods: Eight children and young people (CYP), aged 14 (12-15) years, who were diagnosed with CFRD aged 12.8...

Introduction: Early onset diabetes mellitus and poor glycaemic control can predispose to various long-term complications. NICE recommends regular assessment starting at 12 years of age to diagnose micro/macro vascular complications and neuropathy for appropriate management. Rare undiagnosed metabolic disorders could pose diagnostic and management challenges. We report an unusual presentation of a rare metabolic disorder in an adolescent with type-1 diabetes mellitus (T1D)....

Background: FreeStyle Libre flash glucose monitoring system (FSL) has recently gained popularity as it can potentially reduce the number of finger prick capillary blood glucose tests (CBG). Initial short-term studies in adults have demonstrated accuracy although there is no paediatric data available to date. We aimed to assess the accuracy of FSL in children and young people and evaluated the user experience in routine clinical practice.Methods: About 31...